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Bills vs. Saints, 11/25/21 Thanksgiving Day NFL Betting Predictions & Odds

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Bills vs. Saints Thanksgiving Prediction

Bills vs. Saints, 11/25/21 Thanksgiving Day NFL Betting Predictions & Odds

The third and final game of the NFL Thanksgiving Day triple-header is a non-conference matchup between the Bills and Saints at 8:20 p.m. ET. With how banged-up New Orleans is, will Buffalo cover as a 6-point road favorite or is there a better play on the board?

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